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瑞芬太尼 (remifentanil)是最新的 μ阿片受体激动剂 ,药效强 ,起效迅速 ,剂量容易控制 ,安全可靠。该药是哌啶的衍生物 ,因含有一个酯的结构 ,极易被体内酯酶迅速水解。对循环、呼吸、神经系统的作用是剂量依赖型的 ,对肝、肾功能无损害作用 ,容易通过胎盘 ,但在胎儿体内迅速代谢 ,不会引起胎儿的呼吸抑制。当成人剂量为 0 .2～ 1.0 μg·kg- 1·min- 1,血浆浓度为 5～ 8μg·L- 1时 ,作用达到顶峰。滴注时间长短并不影响贯连敏感半时值 (context sensitivehalf time) ,因而苏醒快。此药已应用于各类大小手术。因其制剂含有甘氨酸 ,故不能用于硬膜外腔。剂量较大并与其他麻醉药共同应用时 ,可引起血压降低和心动过缓
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基本信息:
中图分类号:R971
引用信息:
[1]盛娅仪,徐振邦.瑞芬太尼的药理学和临床应用[J].中国新药与临床杂志,2001(02):142-146.
2001-03-15
2001-03-15